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     Depression is commonly seen as a mood disorder centered in the brain, but it actually affects the entire body. One example is the persistent fatigue that saps a person’s motivation to move. This physical sluggishness isn’t just psychological—it’s tied to metabolic disruptions that reduce both mental and physical energy. Depression touches nearly every bodily system: it disrupts sleep, alters appetite, affects pain sensitivity, weakens immunity, and increases heart disease risk. In fact, many people first seek medical help for physical symptoms like chronic pain or exhaustion, unaware that these may stem from depression.